Unveiling the Journey of Lynch Syndrome
Explore the pivotal moments in the discovery and ongoing research of Lynch Syndrome.
Photo of Henry Lynch,M.D.
Milestones in Lynch Syndrome Discovery
Trace the significant events that have shaped our understanding of Lynch Syndrome over the years.
1885
Initial Identification
Dr. Warthin, a pathologist at the University of Michigan, spoke with his seamstress, who expressed her concern about the possibility of dying from cancer. She explained that numerous relatives in her family, over several generations, had succumbed to uterine or “abdominal” cancer at a young age, which led her to fear she might be next.
1912-1931
Dr. Warthin published a paper documenting the history of uterine and “abdominal” cancers in his seamstress’s family, which he identified as Family G. He proposed that, at least in this family’s case, there could be a genetic predisposition to cancer.
1966-1971
Dr. Henry Lynch studied numerous other family histories that exhibited clusters of cancer. Having reviewed Dr. Warthin’s work on Family G, he arranged a reunion with the family to gain deeper insights. He obtained data on. > 650 family members. Through his medical genetic research, he introduced the term “Cancer Family Syndrome” to describe the recurrent cancer patterns in these families. Dr. Henry Lynch identifies a hereditary pattern in colorectal cancer, marking the first step in understanding Lynch syndrome.
1985
Dr. Lynch initially coined the term “hereditary non-polyposis colorectal cancer syndrome” (HNPCC) to distinguish it from other colorectal cancer syndromes that caused numerous polyps, as the families he was studying had relatively few polyps. Dr. Richard Boland names it Lynch Syndrome, in recognition of Dr. Lynch’s pioneering work.
1993-1995
Gene Testing Advances
Introduction of genetic testing for Lynch syndrome, allowing for early detection and better management of the condition.
2000
Increased Awareness
Global awareness campaigns begin, highlighting the importance of early diagnosis and family screening. Medical school curriculum starts to include information about Lynch Syndrome.
2025
Currently 1 in 279 people has Lynch Syndrome, however 95% of those still have not been diagnosed.
Lynch Syndrome is the most commonly inherited cancer syndrome that raises person’s risk for Colorectal Cancer. It is the most common hereditary predisposition for Uterine Cancer.
The exciting news is there are many more medical studies and advancements happening.
Research Breakthroughs in Lynch Syndrome
Over the years, significant strides have been made in understanding Lynch syndrome, leading to improved diagnostic techniques and treatment options. Researchers have identified key genetic markers that aid in early detection, offering hope for better management of this hereditary condition.